Individuals with Type 2 diabetes secrete glucose into their small intestine, which gut microbiota in the large intestine consume to produce short-chain fatty acids. The rate of glucose secretion is four times higher in those who are taking metformin. Intestinal secretion of glucose was also observed in mice. Feeding of the gut microbiome with glucose is a novel observation.
Summary: https://www.eurekalert.org/news-releases/1074776
Original paper: https://www.nature.com/articles/s43856-025-00755-4