"On improving the sustainability of peer review" - a good editorial from #PLOSBiology https://doi.org/10.1371/journal.pbio.3003127 #peerreview #academicchatter #academicpublishing
How does the lysogenic-lytic cycle work in intestinal #bacteriophages? @dbikard &co show that hankyphage produces defective viral particles & identify RepCHP as master repressor of this #phage's lytic cycle #plosbiology https://plos.io/41Rr22S
How does sensory information construct representations in the human brain? This study shows that a network including prefrontal & posterior #ParietalCortex & anterior #insula has a key role in translating perceptual information to concepts, semantics & action plans #plosbiology https://plos.io/4lbXN2b
Sleep regulation in #Drosophila. @dissel_lab1 &co show that #cholinergic #neurons in the dorsal fan-shaped body (dFB) play a major role in #sleep modulation in this neurochemically heterogeneous region of the fly brain #plosbiology https://plos.io/42uPczp
How do worms navigate based on learned experience? @AndrewLeifer &co reveal flexible behavioral strategies & distributed neural computations underlying learning-dependent odor #navigation in #Celegans #plosbiology https://plos.io/4bYZs7c
Sleep can support #memory, but can memory hyperfunction cause #sleep deficits? They find that the short-sleep #Drosophila mutant "#insomniac" has enhanced memory and that PKA signaling balances sleep & memory in these flies #plosbiology https://plos.io/4ihHNtL
The Shh pathway is a key regulator of feather development. @rorylcooper & @lanevol show that inhibiting Shh during chick embryogenesis results in unbranched #feather buds, similar to those seen in some of their #dinosaur ancestors #plosbiology https://plos.io/4bIYQCx
Analysis of #IUCNRedList data on 67,217 animal species reveals that a range of #conservation actions successfully conserved species at greatest risk of extinction, but rarely resulted in full recovery #plosbiology https://plos.io/3XUzEDd
Secretion mechanisms of many T6SS effectors in Gram-neg #bacteria remain unclear. @DrDorSalomon &co identify a new class of #T6SS effectors, which can harbor either 1 or 2 toxic domains and use the WHIX domain as a secretion motif #plosbiology https://plos.io/4iCxVL3
Bright colors observed across the animal world are often used during mate choice. @dickmerrill explores a #plosbiology study of genetic & neural mechanisms contributing to evolution of visual mating decisions in Heliconius butterflies. Paper: https://plos.io/4iHQDRd Primer: https://plos.io/4ipW7QS
Current methods for profiling #HistoneModifications require cell isolation & don't work with all tissue types. @jellevda &co adapt Targeted DamID (TaDa) to profile cell-type-specific #histone marks throughout the genome, in vivo, without cell isolation #plosbiology https://plos.io/3Dw8sUD
Neural circuits that link genetic variation to #behavior: This study of mate choice behavior in Heliconius cydno #butterflies shows that alterations to the peripheral nervous system, driven by genetic & gene expression differences, can alter essential behaviors #plosbiology https://plos.io/4iHQDRd
A role for translational control in stem & differentiating cells. This study shows that signals from the #StemCell niche induce changes in translational rates (via eIF3d1 phosphorylation) to control stem cell fate in #Drosophila testis #plosbiology https://plos.io/3Dw1W07
Bacterial ABC peptide transporters are involved in processes like nutrient uptake. This study solves #cryoEM structures of the #Ecoli dipeptide #transporter DppABCDF in both apo & ATP analog-bound forms, providing insights into assembly & import mechanism #plosbiology https://plos.io/3DxP8pU
Intercellular interactions between DIP & Dpr proteins coordinate #NeuralNetwork assembly in flies, but what if they're expressed in the same cell? This study shows that DIPs & Dprs can interact in cis, & that the cis/trans balance plays a role in neural development #plosbiology https://plos.io/3XpRs9f
#Sorghum develops aerial roots and (like maize) produces abundant carb-rich mucilage after rain. @jeanmichelane &co show that diazotrophic #bacteria in the aerial roots can fix nitrogen, reducing need for synthetic fertilizers #plosbiology https://plos.io/3EYPZjK
Dynamics of a supergene. A study of the BC supergene in wing color morphs of the African monarch #butterfly by @rishidekayne &co reveals dynamic evolution of #supergene haplotypes, fueled by incomplete recombination suppression #plosbiology https://plos.io/3DiFhnL
When did the lubricated joints that allow our skeleton to swivel, rotate and bend evolve? Gage Crump explores a new #plosbiology paper by @neelimasharma @neilshubin &co that pinpoints their origin to the earliest jawed vertebrates. Paper: https://plos.io/3CTC8La Primer: https://plos.io/4kkhXa6
When did synovial joints evolve? @neelimasharma @neilshubin &co reveal that stable, mobile & lubricated joints were present in the common ancestor of jawed fishes but lacking in jawless ones #plosbiology https://plos.io/3CTC8La
ZBP1 initiates RIPK3-mediated #necroptosis during #viral infection in mouse cells, but what about human cells? This study shows that in humans RIPK1 is required for HSV-induced ZBP1-dependent necroptosis; RIPK1's RHIM motif dictates this species difference #plosbiology https://plos.io/3QxqHfe
