6. 7/8 
Future prospects: there was so little biochemical data for our specific proteins, we had to rely on genome-wide data (PBMs). We could then estimate Kd for ANY sequence. That means, also for sequence variants.
Our earlier Framework Model v2 (FMv2) and FM-Life models link the clock right up, through plant metabolism, growth, development and physiology, to seed-to-seed adaptation in real weather.
Anyone who assembles these parts gets to predict how an Arabidopsis genome sequence variant will be adapted to climatic conditions. With a full causal chain. The mechanisms of evolutionary adaptation.
#GoForIt
Sure it’s simplified and there’s much to validate but it’s there. DNA-binding Kd is just where we started, there’s more known biochemistry to add.
