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#AlphaFold2

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🧬 #Proteine: Bausteine des Lebens

Die 3D-Struktur von Proteinen allein aus ihrer Sequenz vorherzusagen, war lange ungelöst. 2020 schafften Demis Hassabis und John Jumper mit #AlphaFold2 den Durchbruch – ausgezeichnet mit dem #ChemieNobelpreis 2024. 🏆

🔍 Was macht AlphaFold2 🤖 so besonders? Alexander Schug vom @fzj_jsc erklärt es diese Woche bei #WissenschaftOnline.

👉 Infos & Login: fz-juelich.de/de/ueber-uns/kon

Continued thread

Having identified the proteins, I fetch their #AlphaFold2 predictions from AlphaFold-DB, or compute them if not in the DB. #AF2 models have excellent geometry and complete sequence correctly numbered, so they are excellent starting models. I rarely use #PDB entries as starting models anymore. Rare exceptions: a PDB entry I deposited myself, or one containing a post-translational modification or non-natural amino acid I need (never present in #AF2 models, only the 20 standards amino acids).
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