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#mechanical

2 posts2 participants0 posts today
Public
Rxiv mechanobio

📰 "Tissue-like compression stiffening in biopolymer networks induced by aggregated and irregularly shaped inclusions"
biorxiv.org/content/10.1101/20 #Mechanical #Cell

bioRxiv · Tissue-like compression stiffening in biopolymer networks induced by aggregated and irregularly shaped inclusionsBiological tissues experience mechanical compression under various physiological and pathological conditions and often exhibit compression stiffening, in which their stiffness increases during compression, a phenomenon that plays a crucial role in regulating cell behavior and maintaining mechanical homeostasis. However, most isolated biopolymer networks, such as fibrin and collagen hydrogels that form the extracellular matrix and actin network that forms the internal cytoskeleton, undergo compression softening, raising questions about how tissues achieve compression stiffening despite the softening properties of their extracellular and intracellular matrix components. Previous studies have shown that spherical inclusions at large volume fractions can induce compression stiffening in biopolymer networks, but they do not account for the effects of aggregation and irregular morphologies of cellular assemblies or other components in tissues. Here, we demonstrate a novel mode of compression stiffening induced by aggregated or irregularly shaped inclusions that occurs at significantly lower volume fractions. Using carbonyl iron particles and coffee ground particles, we find that the morphological diversity of inclusions enables tissue-like compression stiffening at a low volume fraction of inclusions. Through a set of experiments and computational analyses, we demonstrate that these particles can percolate at low volume fractions. We further show that the percolation of stiff inclusions creates a stress-supporting network and enables tension-dominated stress propagation in fibrin fibers, both of which drive macroscopic stiffening during compression. These findings provide insights into the regulation of tissue stiffness and have implications for designing biomaterials with physiologically relevant mechanical properties for biomedical applications. ### Competing Interest Statement The authors have declared no competing interest. US National Science Foundation, DMR-2309043, CMMI-1548571 National Institute of General Medicine Sciences, R35-GM-136259 National Institute of Biomedical Imaging and Bioengineering, R01-EB-017753 Eric and Wendy Schmidt AI in Science Postdoctoral Fellowship
Public
dr 🛠️🛰️📡🎧:blobfoxcomputer:

In the last 3ish years, we've had #trans and now #progress #pride flags outside on our extremely visible but also surprisingly windy corner

In that time, we've gone through 3-4 flag poles thanks to bad #design and cheap construction

I kinda want to #diy this bc it can't be this hard

Design constraints:

- 3'x5' (1x1.5m) flag
- long dimension of flag parallel to the ground
- 6-8' (2-2.5m) tall
- very strong in bending (windy corner)
- weighted bottom rather than dug (ground is usually frozen, rocky or mud)
- not "ugly"

Naively, I'd stick an iron or PVC pipe in a bucket of cement, then mount the flag with rotating clips. But even painted, I can't claim this isn't "ugly".

The base needs to be smaller. How heavy/wide do I really need? How would I even measure the torque the wind is applying? I guess a spring scale and just pull the pole to about the same bending I see from the wind....?

Is there a flag pole design standard?

#mechanical #engineering

(I've seen the "RV style" and it's clever, but not quite the look I want.)

Replied in thread
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Dendrobatus Azureus

@mkj @systemz

One thing that SSD's still can't do, Is keep your data Safe for periods similar to that of mechanicals without being powered up every Year.

Too many people have complained about using SSD as offline storage and came to realize that after a year and a half, of being offline a significant amount of the data was gone.

It must be technically feasible to make a pure mechanical HDD that has higher throughputs.

#Data#Backup#Amiga
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Dendrobatus Azureus

Right as we speak a copy of one of my large audio projects is made to a mechanical HDD. I ask myself why technology has not evolved in a way that single consumer grade drives can take the TB of data they hold in at speeds that are proportional to their size.

It takes 10 minutes for a puny 100GB to be transferred at about 160MB/s from the M.2 SSD to the mechanical spinner which still rotates at that lousy 7200RPM.

My Ultrawide SCSI Fijitsu HDD on my A4000T rotated at 10.000RPM! That HDD is from the last century!!!

IT still works!

If HDD companies put in the proper research we may not be having 20.000RPM drives on servers, because of mechanical limits, but we should have had 10.000 rpm drives now for consumer grade mechanical HDDs.

Legenda:
1TB = 1024GigaBytes
1MB = 1024Bytes

The screencap shows a computer screen displaying a file manager interface, specifically the Midnight Commander (mc) software. The interface is split into two panes, with the left pane showing a directory path starting with "/.../audacity_temp" and the right pane showing a directory path starting with "/.../metalloid/audio/raw/audacity". The left pane lists various files and directories with their names, sizes, and modification times, while the right pane shows a file transfer operation in progress. The file being copied is "06_00_03_nov_2K24_masterTape_t80_rx1602_behringer.aup3" from the source directory to the target directory "/media/metalloid/SwiftFatu_Pu_t80_rx1602_behringer.aup3". The transfer is 9% complete with an estimated time of arrival (ETA) of 0:09.11 at a speed of 166.47 MB/s. The interface includes buttons for "Skip," "Suspend," and "Abort" the operation. The bottom of the screen shows a status bar with various options and a hint about key bindings. The overall color scheme is blue and black, typical of the Midnight Commander software.
#Data#Backup#Amiga
Public
Bytes Europe

– 360° virtual reality inspires more environmental charity donations byteseu.com/886786/ #adhesives #Automation #bearings #design #DesignEngineering #DpaMagazine #drives #electrical #electronic #enclosures #EngineeringSoftware #environment #fasteners #hydraulics #MachineBuilding #Materials #mechanical #MotionControl #Motors #pneumatics #Sensors #springs

Bytes Europe · – 360° virtual reality inspires more environmental charity donations02 April 2025According to psychologists, virtual reality nature documentaries have a stronger impact on viewers than traditional videos, increasing awareness of climate change.Image: ShutterstockA group of media psychologists at the University of Cologne, led by Professor Dr Kai Kaspar, has examined the effects of presenting environmental protection documentaries by way of 360° virtual reality (VR) videos compared with the use of other more traditional media forms. VR videos are interactive 360° videos that allow viewers to immerse themselves in a digital environment and explore it from different angles, often with the help of VR headsets or glasses. According to the study participants,
Public
Víctor Vicente-Palacios

Great episode of #TechWontSaveUs with @timnitGebru

It's a real pleasure to listen to such a rich conversation on such diverse topics.

I especially liked how the topic of how the #AI industry labels people and methods was addressed.

It's the same for me, I've ended up assuming I'm a #DataScientist when I'm actually a #mechanical #engineer with a #PhD in #statistics. But the industry has decided that what I am is something I haven't studied about.

techwontsave.us/episode/267_ai

Tech Won't Save UsAI Hype Enters Its Geopolitics Era w/ Timnit Gebru - Tech Won’t Save UsA left-wing podcast for better technology and a better world.
Public
Rxiv mechanobio

📰 "Osmotic pressure induces unexpected relaxation of contractile 3D microtissue"
biorxiv.org/content/10.1101/20 #Mechanical #Cell

bioRxiv · Osmotic pressure induces unexpected relaxation of contractile 3D microtissueCell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects tissue contractility, a hallmark of tissue function, is however unknown. Here we apply osmotic compression to microtissues of either mouse colon adenocarcinoma CT26 cells, mouse NIH 3T3 fibroblasts, or human primary colon cancer-associated fibroblasts. Microtissues are anchored to flexible pillars that serve as force transducers. We observe that low-amplitude osmotic compression induces a rapid relaxation of tissue contractility, primed by the deformation of the extracellular matrix. Furthermore, we show that this compression-induced relaxation is independent of the cell type, proportional to the initial tissue contractility, and depends on RhoA-mediated myosin activity. Together, our results demonstrate that compressive stress can relax active tissue force, and points to a potential role of this feedback mechanism during morphogenetic events such as onco- or embryogenesis. ### Competing Interest Statement The authors have declared no competing interest.
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