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#mechanical

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@mkj @systemz

One thing that SSD's still can't do, Is keep your data Safe for periods similar to that of mechanicals without being powered up every Year.

Too many people have complained about using SSD as offline storage and came to realize that after a year and a half, of being offline a significant amount of the data was gone.

It must be technically feasible to make a pure mechanical HDD that has higher throughputs.

#Data#Backup#Amiga

Right as we speak a copy of one of my large audio projects is made to a mechanical HDD. I ask myself why technology has not evolved in a way that single consumer grade drives can take the TB of data they hold in at speeds that are proportional to their size.

It takes 10 minutes for a puny 100GB to be transferred at about 160MB/s from the M.2 SSD to the mechanical spinner which still rotates at that lousy 7200RPM.

My Ultrawide SCSI Fijitsu HDD on my A4000T rotated at 10.000RPM! That HDD is from the last century!!!

IT still works!

If HDD companies put in the proper research we may not be having 20.000RPM drives on servers, because of mechanical limits, but we should have had 10.000 rpm drives now for consumer grade mechanical HDDs.

Legenda:
1TB = 1024GigaBytes
1MB = 1024Bytes

#Data#Backup#Amiga

Great episode of #TechWontSaveUs with @timnitGebru

It's a real pleasure to listen to such a rich conversation on such diverse topics.

I especially liked how the topic of how the #AI industry labels people and methods was addressed.

It's the same for me, I've ended up assuming I'm a #DataScientist when I'm actually a #mechanical #engineer with a #PhD in #statistics. But the industry has decided that what I am is something I haven't studied about.

techwontsave.us/episode/267_ai

Tech Won't Save UsAI Hype Enters Its Geopolitics Era w/ Timnit Gebru - Tech Won’t Save UsA left-wing podcast for better technology and a better world.

📰 "Osmotic pressure induces unexpected relaxation of contractile 3D microtissue"
biorxiv.org/content/10.1101/20 #Mechanical #Cell

bioRxiv · Osmotic pressure induces unexpected relaxation of contractile 3D microtissueCell contraction and proliferation, matrix secretion and external mechanical forces induce compression during embryogenesis and tumor growth, which in turn regulate cell proliferation, metabolism or differentiation. How compression affects tissue contractility, a hallmark of tissue function, is however unknown. Here we apply osmotic compression to microtissues of either mouse colon adenocarcinoma CT26 cells, mouse NIH 3T3 fibroblasts, or human primary colon cancer-associated fibroblasts. Microtissues are anchored to flexible pillars that serve as force transducers. We observe that low-amplitude osmotic compression induces a rapid relaxation of tissue contractility, primed by the deformation of the extracellular matrix. Furthermore, we show that this compression-induced relaxation is independent of the cell type, proportional to the initial tissue contractility, and depends on RhoA-mediated myosin activity. Together, our results demonstrate that compressive stress can relax active tissue force, and points to a potential role of this feedback mechanism during morphogenetic events such as onco- or embryogenesis. ### Competing Interest Statement The authors have declared no competing interest.

I just bought a new #mechanical #keyboard. But this one is weird as the escape key doubles as the backquote key. Because of this, the only way to access the backquote key is to press fn+escape, then escape again, then fn+escape to go back to 'escape' mode for the key. Thankfully, it also has keys I never use, like INSERT! Using #keyd, I could remap INSERT to the backquote key with the following config (works in #wayland):

```
cat /etc/keyd/default.conf
[ids]

*

[main]
insert = grave
```

📰 "The mechanics of a continuous self-assembling surface-layer aids cell division in an archaeon"
biorxiv.org/content/10.1101/20 #Mechanical #Mechanics #Cell

bioRxiv · The mechanics of a continuous self-assembling surface-layer aids cell division in an archaeonThe surface layer or "S-layer" is a planar lattice of glycosylated proteins that coats a wide range of archaea and bacteria instead of a classical cell wall or capsular polysaccharides, insulating them from the extracellular space and providing the cell membrane with physical support. Although the S-layer's role as a mechanical support for the membrane might be expected to hinder cell division, we show that in rapidly dividing Sulfolobus acidocaldarius cells, the S-layer protein SlaA self-assembles into flexible lattice that helps flattens the cytokinetic furrow to accelerate ESCRT-III dependent cell division - a role that is especially important under conditions of mechanical stress. Taken together, these results generated using mutational analysis, live and fixed cellular imaging, along with electron cryomicroscopy, define the rules governing S-layer self-assembly and show how the mechanical properties of flexible lattice coats can enhance membrane functions to both physically support a cell and help to drive ESCRT-III dependent cell division. ### Competing Interest Statement The authors have declared no competing interest.

📰 "Mechanical and functional characterisation of a 3D porous biomimetic extracellular matrix to study insulin secretion from pancreatic beta-cell lines"
doi.org/doi:10.1007/s44164-024
pubmed.ncbi.nlm.nih.gov/398726
#Extracellular #Mechanical #Matrix

SpringerLinkMechanical and functional characterisation of a 3D porous biomimetic extracellular matrix to study insulin secretion from pancreatic β-cell lines - In vitro modelsBackground Extracellular matrix (ECM) is a three-dimensional (3D) structure found around cells in the tissues of many organisms. It is composed mainly of fibrous proteins, such as collagen and elastin, and adhesive glycoproteins, such as fibronectin and laminin—as well as proteoglycans, such as hyaluronic acid. The ECM performs several essential functions, including structural support of tissues, regulation of cell communication, adhesion, migration, and differentiation by providing biochemical and biomechanical cues to the cells. Pancreatic β-cells have been previously shown to be responsive to the surrounding mechanical stress, impacting their insulin-secreting function. Purpose We aimed to derive a physiologically relevant in vitro model of pancreatic tissue by using an innovative synthesised porous ECM that mimics the native tissue microenvironment and mechanical properties. Methods Here we performed mechanical, physico-chemical and functional characterisation of a synthetic hydrogel ECM, composed of hyaluronic acid cross-linked with collagen types I and VI and modified with fibronectin. The hydrogel was used as a 3D cell culture scaffold for the MIN6 insulinoma cell line. Cell proliferation, viability, gene expression, and insulin secretion in response to glucose stimulus were assessed and contrasted with classic monolayer culture. Results The biomaterial exhibited a shear modulus of 815.37 kPa and a distinctive viscoelastic response. MIN6 cells showed a higher proliferation and viability rates and maintained insulin secretion in response to glucose stimulus and β-cell identity gene expression when cultured in the 3D hydrogel compared to monolayer culture. Conclusion Our study demonstrated the potential of this biomimetic hydrogel scaffold as an innovative matrix enabling better in vitro models to study disease physiopathology.

I'm drowning in work right now, but yesterday I did manage to pop the lid of my #GeminiMicrocomputers parallel #keyboard.

It's a full #metal frame #mechanical keyboard with silver pad style switches, way before everything had to go click. It's covered a thick layer of dirt, but I'm doing an in-depth cleaning when I have a little more time.

Also, it's untested and currently doesn't have a cable. I'll look into that as well.

The ROM contained "(C)1978 INTEL CORP".