6. 7/8 Future prospects: there was so little biochemical data for our specific proteins, we had to rely on genome-wide data (PBMs). We could then estimate Kd for ANY sequence. That means, also for sequence variants.

Our earlier Framework Model v2 (FMv2) and FM-Life models link the clock right up, through plant metabolism, growth, development and physiology, to seed-to-seed adaptation in real weather.

Anyone who assembles these parts gets to predict how an Arabidopsis genome sequence variant will be adapted to climatic conditions. With a full causal chain. The mechanisms of evolutionary adaptation. #GoForIt

Sure it’s simplified and there’s much to validate but it’s there. DNA-binding Kd is just where we started, there’s more known biochemistry to add.

@luis_in_brief agreed. I am stepping off of the notion of being FOSS activist in the traditional sense of the word.

#FOSS in a new definition I reserve solely to arranging the #copyright and other #legal matters relating to the delivered artifacts of a project.

Then the real deal is #SOSS where a holistic #sustainability-first approach is taken to #FreeSoftware #development, that covers the entire #lifecycle.. from hobby #project up to foundational #technology or mega #SocialWeb platform.

@rysiek @agturcz that's not how you fix #TechIlliteracy, espechally since things changed for the better.

@monocles / #monoclesChat & @gajim / #gajim are quite easy, whereas @signalapp / #Signal demands #PII in the form of a #Phone number which is more often than not not legally obtainable without "#KYC" aka. "forced #SelfDoxxing" all whilst being an extremely #centralized, #SingleVendor & #SingleProvider solution that falls under #CloudAct ant thus cannot adhere to #GDPR & #BDSG!

• Sorry, but "#TechPopulism" alike "JuSt UsE sIgNaL !" won't fix #TechIlliteracy but rather provide false sense of security to #TechIlliterates when the correct solution is to teach proper #TechLiteracy like @cryptoparty@chaos.social / @cryptoparty@mastodon.earth / #CryptoParty does...

Otherwise we'd only perpetuate the #Enshittification-#Lifecycle as has happened with #AIM, #ICQ, #BBM and so many more...

• Mark my words, cuz I've been proven correct up to this point.

If #Signal and @Mer__edith actually cared, they would've setup their system truly decentralized as an #OnionService over @torproject / #Tor!